Disruption of Dicer1 Induces Dysregulated Fetal Gene Expression and Promotes Hepatocarcinogenesis
نویسندگان
چکیده
منابع مشابه
Questioned validity of Gene Expression Dysregulated Domains
Recently, in studies examining fibroblasts obtained from the tissues of one set of monozygotic twins (i.e. fetuses derived from the same egg) discordant for trisomy 21 (Down syndrome; DS), Letourneau reported the presence of a et al., defined pattern of dysregulation within specific genomic domains they referred to as ene xpression ysregulated omains (GEDDs). GEDDs were G E D D described a...
متن کاملGeneralized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth.
Monoallelic expression of imprinted genes, including ones solely expressed in the placenta, is essential for normal placental development and fetal growth. To better understand the role of placental imprinting in placental development and fetal growth, we examined conceptuses developing in the absence of maternally derived DNA (cytosine-5-)-methyltransferase 1o (DNMT1o). Absence of DNMT1o resul...
متن کاملHyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial–Mesenchymal Transition, and Kidney Tubular Injury in Mice
Background: Hyperuricemia contributes to kidney injury, characterized by tubular injury with epithelial–mesenchymal transition (EMT). Wnt5a/Ror2 signaling drives EMT in many kidney pathologies. This study sought to evaluate the involvement of Wnt5a/Ror2 in hyperuricemia-induced EMT in kidney tubular injury.Methods: A hyperuricemia model was performed in male Swiss background mice (3 months old,...
متن کاملQuestioned validity of Gene Expression Dysregulated Domains in Down's Syndrome.
Recently, in studies examining fibroblasts obtained from the tissues of one set of monozygotic twins (i.e. fetuses derived from the same egg) discordant for trisomy 21 (Down syndrome; DS), Letourneau et al., ( )reported the presence of a defined pattern of dysregulation within specific genomic domains they referred to as Gene Expression Dysregulated Domains (GEDDs). GEDDs were described as alte...
متن کاملExpression of the p53 Tumor Suppressor Gene Induces Differentiation and Promotes Induction of Differentiation
Leukemic U-937 cells, which lack normal p53, were stably transfected with a temperature-sensitive mutant of p53 to investigate the consequences for growth and differentiation. On induction of wild-type p53 activity at the permissive temperature, some of these cells underwent maturation as judged by the capacity for oxidative burst and the appearance of monocyte related cell surface molecules. M...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2009
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2009.02.067